Innervation plays a pivotal role in the development and functional control and modulation of tissues and organs. The vagus nerve innervates peripheral directly connecting them to the brain. This brain-body communication highlights the vagus nerve as a naturally designed therapeutic tool for a wide spectrum of both central and peripheral diseases.From a neuroscientific perspective, the vagus nerve serves as a vital pathway for bi-directional signaling between the brain and peripheral organs. Electrical vagus nerve stimulation (VNS) has been a subject of intense research since its inception in the 19th century, but it only began to gain widespread recognition in the 1990s with FDA approval for treating refractory central nervous system disorders, such as epilepsy and depression. More recently, advances in our understanding of the vagus nerve’s robust global anti-inflammatory properties and the development of non-invasive VNS devices—offering similar efficacy with improved safety profiles compared to invasive