Proof of concept: short-term non-invasive cervical vagus nerve stimulation in patients with drug-refractory gastroparesis

Emma Paulon,1 Despoina Nastou,1 Francesca Jaboli,1 Juana Marin,2 Eric Liebler,3 Owen Epstein1

1Royal Free London NHS Foundation Trust, London, UK 2NIHR-Wellcome Trust Clinical Research Facility, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK 3electroCore, LLC, Basking Ridge, New Jersey, USA

ABSTRACT
Background Gastric electric stimulation (GES) is a treatment approach to refractory gastroparesis, possibly acting centrally via afferent vagus nerve stimulation (VNS). Non-invasive VNS (nVNS) is a potential alternative to GES that could eliminate the safety risks of or identify likely responders to implantable neurostimulator.

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